VenomTech firm declares large library of SNAKE VENOM peptides for pharmaceutical growth; “nanocarriers” stabilize snake venom in WATER (PubMed)
Astonishingly, it’s quickly turning into obvious within the aftermath of the Dr. Bryan Ardis revelations about snake venom origins for covid-19 that many individuals — even some in alt media — are utterly unaware that snake venom is usually used as the place to begin for pharmaceutical analysis.
Earlier as we speak, a UK firm actually named “Venomtech” introduced an enormous venom peptide and venom fragment library for use for drug discovery by pharmaceutical firms (in addition to pesticide used for agricultural firms).
The information was extensively coated within the biotech media, together with at Information-Medical.internet, which revealed the announcement, “Venomtech declares new drug growth collaboration with Charles River.”
From that announcement:
Venomtech is collaborating with Charles River Laboratories, Worldwide Inc. to assist drug builders discover venom-derived compounds for a variety of therapeutic targets. This newly fashioned collaboration will convey collectively Venomtech’s biology experience and huge venom-derived peptide library, with Charles River’s drug growth and screening knowhow, offering pharmaceutical producers with a one-stop service to discover this distinctive pure useful resource.
Venomtech’s Focused-Venom Discovery Array™ (T-VDA™) libraries present researchers with a simple resolution to quickly display screen 1000’s of particular person venom fragments, with every array particularly designed to maximise hits for a particular goal.
The announcement carries this assertion from Venomtech CEO Paul Grant:
Venomtech has been on the forefront of venom analysis for drug discovery for greater than a decade… we will now showcase our modern know-how, introducing the broader trade to the potential of venoms for the profitable supply of extra leads, extra shortly, for a broad vary of [cellular] targets.
…we will now provide our shoppers entry to bespoke venom libraries, doubtlessly accelerating their [drug] discovery pipelines utilizing this highly effective pure useful resource.
The Venomtech firm is described as follows:
Venomtech is a world chief for venom analysis enterprises, primarily based out of world-class laboratories at Discovery Park in Kent, UK.
…[we are] serving to our prospects worldwide make pioneering advances in drug discovery, crop safety, and cosmetics. Now we have the largest library of naturally sourced venom-derived compounds within the UK, from a rising assortment of vertebrate and invertebrate species
Notice that Venomtech’s shoppers embody pharmaceutical firms, pesticides firms and beauty product producers. Venom-based molecules are extensively utilized in drug analysis and different areas of biotech.
So to these within the company media — and even in alt media — who’re expressing shock and dismay at Dr. Ardis claiming that snake venom is the almost certainly origin for analysis into SARS-CoV-2 gain-of-function enhancement and even covid vaccines, you’re blind to the state-of-the-art in biosciences.
The usage of snake venom in prescription drugs isn’t a “conspiracy concept.” It’s a typical follow, representing what most bioscience specialists would describe because the slicing fringe of drug discovery.
For the document, by the way in which, we’re not ascribing any nefarious accusations to the Venomtech firm right here. We point out them solely to show to any skeptics that snake venom is, in actual fact, extensively used as a useful resource for pharmaceutical growth (and it has been for many years).
What Dr. Ardis has claimed will not be science fiction. It’s the state of bioscience in 2022.
Anybody dismissing the “snake venom” concept in relation to covid remedies or vaccines is flatly blind to the assets utilized in as we speak’s drug discovery pipelines.
20,000 kinds of venom peptides
As VenomTech says on their very own drug discovery web page:
Our naturally derived peptide, protein, and small molecule compounds allow pioneering views and options which have confirmed efficient even on hard-to-hit targets the place conventional approaches have beforehand failed. They have an effect on a wide range of molecular targets, equivalent to ion channels, GPCRs and enzymes, with a excessive diploma of selectivity and efficiency, reaping the advantages of hundreds of thousands of years of evolution fairly than simply over 100 years of drug discovery.
Our prospects have entry to a library of 20,000 peptides, proteins, and small molecules derived from venoms – the biggest library of naturally sourced compounds out there within the UK – equipped as an modern Focused-Venom Discovery Array™ and customized arrays with a demonstrated monitor document of success for drug discovery functions.
We consider the Venomtech firm very possible has a really vivid future in its trade, by the way in which. “Biomimicry” means copying nature, and Massive Pharma has an extended historical past of pirating molecules from nature and turning them into multi billion-dollar revenue facilities. The very best concepts come from nature, in fact, despite the fact that the FDA and different well being regulators declare pure molecules are ineffective and may’t be thought of “drugs.” But Massive Pharma will get most of its blockbuster medicine from pure molecules, equivalent to lovostatin molecules present in crimson yeast rice (now changed into excessive revenue statin medicine).
Always remember that the image for the World Well being Group is a snake and a workers that dominate the planet:
And the image of the American Medical Affiliation (AMA) is a serpent encircling a workers, resembling a DNA strand whereas additionally representing the concept of the serpent’s venom:
World Financial Discussion board brags about medicine produced from venom, admits capability to synthesize venom particles utilizing RNA know-how
For those who’re on the lookout for much more proof that snake venom is utilized in drug growth, check out this text from the World Financial Discussion board, revealed as a part of the WEF’s Annual Assembly of the World Future Councils (2018):
Venomics – the scientific evaluation of venom – gives some groundbreaking options to well being issues from coronary heart illness to diabetes, to managing persistent ache.
Actually, there are already six medicine authorized to be used by the Meals and Drug Administration in the USA which can be derived from venom.
However with 15% of the world’s animals producing venom of some type, we’ve actually solely simply begun to scratch the floor of their potential contribution to drugs.
Captopril is an angiotensin-converting enzyme (ACE) inhibitor, a kind of drug used to deal with hypertension and enhance survival and cut back the danger of coronary heart failure after a coronary heart assault. Its fundamental compound is derived from a species of pit viper present in Brazil.
Prialt, derived from the venom of cone snails, is utilized by a number of the estimated 22 million adults within the US who are suffering from extreme and persistent ache.
Byetta is a part of a brand new wave of medication designed to decrease blood glucose in sufferers with kind 2 diabetes. Its key ingredient, exendin-4, is discovered within the saliva of the Gila monster, a big lizard species native to the southwestern US and northwestern Mexico.
Synthesizing snake venom for mass manufacturing, utilizing RNA know-how
Additionally from that WEF article:
One cause for the rising curiosity on this area is that advances in DNA and RNA know-how permit analysis to be carried out a lot sooner.
As an example, historically, dwell venom can be extracted from the animal, then injected into an unsuspecting dwell rodent or fish to check its impression.
These days, the DNA and RNA of the venom have already been recognized, which permits researchers to synthesize its parts and check out their theories.
Nanocarriers can stabilize snake venom peptides for supply by way of water
In response to Dr. Ardis’ revelations about the opportunity of snake venom peptide supply by way of water techniques, there was nearly derision from sure influencers who declare that snake venom wouldn’t be steady in municipal water techniques. In impact, they’re absurdly claiming that faucet water is anti-venom.
If that have been true, all snake bites may merely be handled by consuming faucet water.
In fact, the Nationwide Library of Medication has revealed a examine that reveals the existence of “nanocarriers” which may stabilize snake venom peptides with a purpose to obtain supply by way of water techniques.
Entitled, “Nanoparticles Functionalized with Venom-Derived Peptides and Toxins for Pharmaceutical Purposes,” the examine summary explains the mechanism by which snake venom peptides are stabilized in water and different options: (emphasis added)
Venom-derived peptides show various organic and pharmacological actions, making them helpful in drug discovery platforms and for a variety of functions in drugs and pharmaceutical biotechnology. Resulting from their goal specificities, venom peptides have the potential to be developed into biopharmaceuticals to deal with numerous well being circumstances equivalent to diabetes mellitus, hypertension, and persistent ache. Regardless of the excessive potential for drug growth, a number of limitations preclude the direct use of peptides as therapeutics and hamper the method of changing venom peptides into prescription drugs. These limitations embody, for example, chemical instability, poor oral absorption, quick halflife, and off-target cytotoxicity. One technique to beat these disadvantages depends on the formulation of bioactive peptides with nanocarriers. A spread of biocompatible supplies at the moment are out there that may function nanocarriers and may enhance the bioavailability of therapeutic and venom-derived peptides for scientific and diagnostic software. Examples of remoted venom peptides and crude animal venoms which were encapsulated and formulated with several types of nanomaterials with promising outcomes are more and more reported.
So for anybody who thinks that snake venom can’t be stabilized for supply in water techniques, they clearly don’t know the state of the science. Nanocarriers accomplish the duty fairly merely.
When you develop into conscious of Massive Pharma’s know-how, Dr. Ardis’ claims don’t appear outlandish in any respect
The underside line in all that is fairly clear: The one individuals lashing out in opposition to Dr. Ardis’ claims about snake venom in covid-19 vaccine formulations or snake venom peptide publicity via numerous environmental vectors (water, air, contact surfaces) are people who find themselves uninformed concerning the widespread use of snake venom peptides in medical analysis and drug supply techniques.
The “shock” that many individuals expertise when first listening to about snake venom utilized in drug growth is an artifact of their lack of awareness about trendy drugs. The widespread use of venom from snakes, lizards, frogs, cone fish, stingrays and different creatures is well-known in pharmaceutical analysis circles. It isn’t a “fringe” concept, nor a conspiracy concept.
It’s a organic reality.
Hundreds of thousands of People swallow reptile venom each single day and name it “drugs”
Keep in mind the WEF article linked above? It states, “Prialt, derived from the venom of cone snails, is utilized by a number of the estimated 22 million adults within the US who are suffering from extreme and persistent ache.”
Hundreds of thousands extra take Captopril, and there are a number of different venom-derived, FDA-approved medicine which can be routinely prescribed by docs.
The irrefutable reality is that hundreds of thousands of People swallow reptile venom each single day. They only name it “meds.”
The truth that most of them are utterly blind to the origins of those substances doesn’t excuse these within the company media or indy media for additionally being ignorant. Those that are going to touch upon Dr. Ardis and the snake venom concept ought to no less than familiarize themselves with the state-of-the-art in biosciences. In the event that they fail to do this, they’re simply flinging nonsense very like Jen Psaki on the White Home.
And haven’t we had sufficient of all of the lies and ignorance in our world? Isn’t it time we listened to individuals whose phrases even have a foundation in actual fact fairly than those that are pushing narratives to guard Massive Pharma’s dishonest narratives?
Listed below are components 1 and a pair of of my current interview with Dr. Bryan Ardis, adopted by my Scenario Replace podcast which additional analyzes what could also be happening with snake venom and covid-19 (additionally now referred to as “Covenom-19”):
And right here’s my Scenario Replace podcast that discusses mRNA transfection transhumanism and the “reptilian-human hybrid” phenomenon:
Uncover extra information-packaged podcasts every day, together with particular experiences, interviews and emergency updates, at:
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